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PROTAC K-Ras Degrader-5

Pan-KRAS degrader 4 (compound 69) is a potent cereblon-based KRAS PROTAC degrader, with a DC50 of [1].

Product Specifications

UNSPSC

12352101

Target

PROTACs; Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-k-ras-degrader-5.html

Purity

97.84

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C#CC1=C(C=CC2=CC(O)=CC(C3=C(C4=NC(OCCN5CCC(CC5)CC6CCN(CC6)CC7CCN(CC7)C8=CC=C9C(N(CC9=C8F)C%10CCC(NC%10=O)=O)=O)=NC(N%11C[C@H]%12N[C@H](CC%12)C%11)=C4C=N3)F)=C21)F

Molecular Formula

C57H63F3N10O5

Molecular Weight

1025.17

References & Citations

[1]Jesus Raul Medina. Cereblon-based kras degrading protacs and uses related thereto. US20240287101A1.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light, stored under nitrogen)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-168669/PROTAC-K-Ras-Degrader-5-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-168669/PROTAC-K-Ras-Degrader-5-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Cereblon; K-Ras

CAS Number

[3052745-16-8]

Available Sizes

Curated Selection

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