PROTAC K-Ras Degrader-5
Pan-KRAS degrader 4 (compound 69) is a potent cereblon-based KRAS PROTAC degrader, with a DC50 of [1].
Product Specifications
CAS Number
[3052745-16-8]
UNSPSC
12352101
Target
PROTACs; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-k-ras-degrader-5.html
Purity
97.84
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C#CC1=C(C=CC2=CC(O)=CC(C3=C(C4=NC(OCCN5CCC(CC5)CC6CCN(CC6)CC7CCN(CC7)C8=CC=C9C(N(CC9=C8F)C%10CCC(NC%10=O)=O)=O)=NC(N%11C[C@H]%12N[C@H](CC%12)C%11)=C4C=N3)F)=C21)F
Molecular Formula
C57H63F3N10O5
Molecular Weight
1025.17
References & Citations
[1]Jesus Raul Medina. Cereblon-based kras degrading protacs and uses related thereto. US20240287101A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon; K-Ras
Available Sizes
Curated Selection
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