AChE-IN-67

AChE-IN-67 (compound 8n) is a potent AChE inhibitor, with an IC50 of 0.033 μM. AChE-IN-67 exhibits activity similar to Donepezil (HY-14566) . AChE-IN-67 exhibits high blood-brain barrier (BBB) permeability. AChE-IN-67 can be used for Alzheimer's disease research[1].

Product Specifications

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ache-in-67.html

Smiles

O=C(N/N=C/C1=CC=CN1)CN(N(C)C(C2=C3C=CC=C2)=O)C3=O

Molecular Formula

C16H15N5O3

Molecular Weight

325.32

References & Citations

[1]Nuha D, et al. Design, synthesis, biological evaluation, and molecular modeling simulations of new phthalazine-1,4-dione derivatives as anti-Alzheimer's agents. Arch Pharm (Weinheim) . 2024 Jul 5:e2400067.