SIIVFEKL (TFA)

SIIVFEKL TFA is a variant of the major MHC class I-restricted epitope SIINFEKL. SIIVFEKL TFA is an antigenic peptide, that can stimulate specific T cells in experimental settings to study the competitive interaction between T cells. SIIVFEKL TFA exhibits low affinity for the OT-I T cell receptor (TCR), and can be used for detection of CD8+ T cells[1].

Product Specifications

UNSPSC

12352209

Target

MHC

Type

Peptides

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/siivfekl-tfa.html

Purity

99.85

Solubility

H2O : ≥ 2 mg/mL

Smiles

CC(C)C[C@@H](C(O)=O)NC([C@H](CCCCN)NC([C@H](CCC(O)=O)NC([C@@H](NC([C@H](C(C)C)NC([C@H]([C@@H](C)CC)NC([C@H]([C@@H](C)CC)NC([C@@H](N)CO)=O)=O)=O)=O)CC1=CC=CC=C1)=O)=O)=O.O=C(C(F)(F)F)O.[x]

Molecular Formula

C46H77N9O12.xC2HF3O2

Molecular Weight

948.16 (free acid)

References & Citations

[1]Petkau G, et al., Zfp36l1 establishes the high-affinity CD8 T-cell response by directly linking TCR affinity to cytokine sensing. Eur J Immunol. 2024 Feb;54 (2) :e2350700.