Mouse anti Human p15 - ink4b

Product Specifications

Background

The p15ink4b tumor suppressor protein shows no cross reactivity with the closely related inhibitors including p16ink4a and p19ink4d. p15ink4b is a specific inhibitor of cdk4/cdk6, and is periodically expressed during cell cycle.

CAS Number

9007-83-4

Synonyms

hp15, p15 ink4b, Cyclin-dependent kinase 4 inhibitor B, Multiple tumor suppressor 2

UniProt

P42772 (Human)

Host

Mouse

Species Reactivity

Human

Isotype

IgG1

Clone

DCS114.1

Conjugation

Unconjugated

Type

Monoclonal Antibody

Source

Mice were immunized with a his-tagged recombinant full length p15 protein recognizing a 15kDa protein

Applications

ICC, WB, IP, IHC (paraffin)

Field of Research

Cell Cycle

Purification Method

Ammonium Sulfate Precipitation

Assay Principle

1-5 µg /mL for Western Blot, Immunohistochemistry, and Immunoprecipitation (co-precipitates cdk4/cdk6)

Stability

See expiration date on vial

Concentration

See vial for Concentration

Form

Provided as solution in phosphate buffered saline with 0,08% sodium azide

Precautions

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

References & Citations

1) C. Sherr, et.al. (1995) Gene , Dev..9, 1149-1163_x000D_ 2) Sakellariou, S., et al. 'Immunohistochemical Expression of P15 (INK4B) and SMAD4 in Advanced Gastric Cancer.' Anticancer Research (2008), 28, 1079-1083