Mouse anti Human p15 - ink4b
Product Specifications
Background
The p15ink4b tumor suppressor protein shows no cross reactivity with the closely related inhibitors including p16ink4a and p19ink4d. p15ink4b is a specific inhibitor of cdk4/cdk6, and is periodically expressed during cell cycle.
Synonyms
hp15, p15 ink4b, Cyclin-dependent kinase 4 inhibitor B, Multiple tumor suppressor 2
UniProt
P42772 (Human)
Host
Mouse
Species Reactivity
Human
Isotype
IgG1
Clone
DCS114.1
Conjugation
Unconjugated
Type
Monoclonal Antibody
Source
Mice were immunized with a his-tagged recombinant full length p15 protein recognizing a 15kDa protein
Applications
ICC, WB, IP, IHC (paraffin)
Field of Research
Cell Cycle
Purification Method
Ammonium Sulfate Precipitation
Assay Principle
1-5 µg /mL for Western Blot, Immunohistochemistry, and Immunoprecipitation (co-precipitates cdk4/cdk6)
Stability
See expiration date on vial
Concentration
See vial for Concentration
Form
Provided as solution in phosphate buffered saline with 0,08% sodium azide
Precautions
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
References & Citations
1) C. Sherr, et.al. (1995) Gene , Dev..9, 1149-1163_x000D_
2) Sakellariou, S., et al. 'Immunohistochemical Expression of P15 (INK4B) and SMAD4 in Advanced Gastric Cancer.' Anticancer Research (2008), 28, 1079-1083
Shipping Conditions
Ambient Temperature
Storage Conditions
Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
Functional Analysis
WB
CAS Number
9007-83-4
Curated Selection
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