AN-3485

AN-3485 is a benzoxaborole analogue and an orally active antagonist of the Toll-like pathway. AN-3485 can inhibit TLR-mediated inflammatory cytokine secretion and has significant anti-inflammatory activity. In addition, AN-3485 also has certain anti-tumor activity[1][2].

Product Specifications

CAS Number

[1213827-99-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Interleukin Related; NF-κB; Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/AN-3485.html

Concentration

10mM

Purity

97.38

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

NCC1=CC(Cl)=C(OC2=CC=C(COB3O)C3=C2)C=C1

Molecular Formula

C14H13BClNO3

Molecular Weight

289.52

Precautions

H302, H315, H319

References & Citations

[1]Dong C, et al. Inhibition of Toll-like receptor-mediated inflammation in vitro and in vivo by a novelbenzoxaborole. J Pharmacol Exp Ther. 2013 Feb;344 (2) :436-46.|[2]Chen Y, et al. Cancer-associated Fibroblasts (CAFs) Regulate Lung Cancer Malignant Progression by Transferring SERPINE2 (PN1) Via Exosomes. Curr Mol Med. 2024 Oct 25.