Iclaprim-d6

Iclaprim-d6 (AR-100-d6) is the deuterium labeled Iclaprim. Iclaprim is a new selective bacterial Dihydrofolate inhibitor, which can inhibit the growth of S. aureus (MRSA) with an MIC90 of 0.06 μg/mL.

Product Specifications

CAS Number

[1130072-57-9]

UNSPSC

12352005

Target

Antibiotic; Bacterial; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Solubility

10 mM in DMSO

Smiles

C(C1=C2C(=C(OC([2H])([2H])[2H])C(OC([2H])([2H])[2H])=C1)OC(C=C2)C3CC3)C=4C(N)=NC(N)=NC4

Molecular Formula

C19H16D6N4O3

Molecular Weight

360.44

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Schneider P, et al. Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria. Bioorg Med Chem Lett. 2003 Dec 1;13 (23) :4217-21.|[3]Kohlhoff SA, et al. Iclaprim. Expert Opin Investig Drugs. 2007 Sep;16 (9) :1441-8.