PU141
PU141 is a selected pyridoisothiazolone HAT inhibitor. PU141 is selective toward CBP and p300. PU141 induces cellular histone hypoacetylation and inhibits growth of several neoplastic cell lines originating from different tissues. Anticancer activity[1].
Product Specifications
CAS Number
[168334-34-7]
UNSPSC
12352005
Target
Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pu141.html
Purity
99.30
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C1N(SC2=NC=CC=C21)CC3=CC=C(C=C3)C(F)(F)F
Molecular Formula
C14H9F3N2OS
Molecular Weight
310.29
References & Citations
[1] M Gajer, et al. Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo. Oncogenesis.2015 Feb 9;4 (2) :e137.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBP/p300
Available Sizes
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