PU141
Product Specifications
UNSPSC Description
PU141 is a selected pyridoisothiazolone HAT inhibitor. PU141 is selective toward CBP and p300. PU141 induces cellular histone hypoacetylation and inhibits growth of several neoplastic cell lines originating from different tissues. Anticancer activity[1].
Target Antigen
Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pu141.html
Purity
99.30
Solubility
DMSO : 100 mg/mL (ultrasonic;warming;heat to 80°C)
Smiles
O=C1N(SC2=NC=CC=C21)CC3=CC=C(C=C3)C(F)(F)F
Molecular Weight
310.29
References & Citations
[1] M Gajer,et al. Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo. Oncogenesis.2015 Feb 9;4(2):e137.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-120290/PU141-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-120290/PU141-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
168334-34-7
Available Sizes
Curated Selection
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