5-Hydroxymethyl-2'-deoxyuridine

5-Hydroxymethyl-2'-deoxyuridine is a nucleoside analog. 5-Hydroxymethyl-2'-deoxyuridine inhibits the replication of multiple human leukemia cell lines with IC50 values of 1.7-5.8 μM. 5-Hydroxymethyl-2'-deoxyuridine prolongs the survival of mice carrying L1210 leukemia. 5-Hydroxymethyl-2'-deoxyuridine can be used for the research of cell replication and leukemia[1][2][3].

Product Specifications

CAS Number

[5116-24-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

HSV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/5-hydroxymethyl-2-deoxyuridine.html

Purity

99.93

Solubility

DMSO : 116.67 mg/mL (ultrasonic)

Smiles

O[C@H]1C[C@H](N2C(NC(C(CO)=C2)=O)=O)O[C@@H]1CO

Molecular Formula

C10H14N2O6

Molecular Weight

258.23

Precautions

H302, H315, H319

References & Citations

[1]Shiau GT, et al. Synthesis and biological activities of 5- (hydroxymethyl, azidomethyl, or aminomethyl) -2'-deoxyuridine and related 5'-substituted analogues. J Med Chem. 1980 Feb;23 (2) :127-33.|[2]Kahilainen LI, et al. 5-Hydroxymethyl-2'-deoxyuridine. Cytotoxicity and DNA incorporation studied by using a novel [2-14C]-derivative with normal and leukemic human hematopoietic cells. Acta Chem Scand B. 1985;39 (6) :477-84.|[3]JA Vilpo, et al. 5-Hydroxymethyl-2′-Deoxyuridine: Studies of Antileukemic Properties in Vitro and in Vivo. Nucleosides and Nucleotides . 1987.