Indican

Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS) . IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4[1][2].

Product Specifications

CAS Number

[487-60-5]

Product Name Alternative

Indoxyl-β-D-glucoside

UNSPSC

12171500

Hazard Statement

H302, H315, H319, H335

Target

Fluorescent Dye; OAT; P-glycoprotein

Type

Dye Reagents

Related Pathways

Membrane Transporter/Ion Channel; Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/indican.html

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic) |Methanol : 83.33 mg/mL (ultrasonic)

Smiles

O[C@@H]1[C@H](O[C@H]([C@@H]([C@H]1O)O)OC2=CNC3=C2C=CC=C3)CO

Molecular Formula

C14H17NO6

Molecular Weight

295.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Shiuan-Pey Lin, et al. Transporter-mediated interaction of indican and methotrexate in rats. J Food Drug Anal. 2018 Apr;26 (2S) :S133-S140.|[2]Yu-Chi Hou, et al. Indoxyl sulfate, a uremic toxin, is biotransformed from indoxyl-beta-D-glucoside (indican) in rats. Toxicon. 2008 Sep 1;52 (3) :440-4.