3,4-Methylenedioxycinnamic acid

3,4-Methylenedioxycinnamic acid is an inhibitor of the 4-hydroxycinnamoyl-CoA ligase (4CL) with a Ki of 100 μM. 3,4-Methylenedioxycinnamic acid exhibits the Km value for the substrate ferulic acid of 4CL is 8.4 μM.3,4-Methylenedioxycinnamic acid increases the formation of soluble phenolics in particular of vanillic acid. 3,4-Methylenedioxycinnamic acid demonstrates larvicidal activity[1][2].

Product Specifications

CAS Number

[2373-80-0]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Parasite

Type

Natural Products

Related Pathways

Anti-infection

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/3-4-methylenedioxycinnamic-acid.html

Purity

99.96

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(O)/C=C/C1=CC=C(OCO2)C2=C1

Molecular Formula

C10H8O4

Molecular Weight

192.17

Precautions

H315, H319, H335

References & Citations

[1]Funk C, Brodelius PE. Phenylpropanoid Metabolism in Suspension Cultures of Vanilla planifolia Andr. : II. Effects of Precursor Feeding and Metabolic Inhibitors. Plant Physiol. 1990 Sep;94 (1) :95-101.|[2]Silva MSL, et al. Biological evaluation of 1,3-benzodioxole acids points to 3,4- (methylenedioxy) cinnamic acid as a potential larvicide against Aedes aegypti (Diptera: Culicidae) . Exp Parasitol. 2024 Jan;256:108657.