TOP2A (Phospho Ser1213) rabbit pAb
Catalytic activity: ATP-dependent breakage, passage and rejoining of double-stranded DNA. enzyme regulation: Specifically inhibited by the intercalating agent amsacrine. function: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. miscellaneous: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils. PTM: Phosphorylation has no effect on catalytic activity. similarity: Belongs to the type II topoisomerase family. subcellular location: Generally located in the nucleoplasm. subunit: Homodimer. Interacts with COPS5.
Product Specifications
Background
Synonyms
DNA topoisomerase 2-alpha (EC 5.99.1.3;DNA topoisomerase II, alpha isozyme)
Gene ID
7153
UniProt
P11388
Cellular Locus
Cytoplasm. Nucleus, nucleoplasm. Nucleus. Nucleus, nucleolus.
Host
Rabbit
Species Reactivity
Human,Rat,Mouse,
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human TOP2A (Phospho Ser1213)
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, ELISA
Validated Applications
WB,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
WB 1:1000-2000 ELISA 1:5000-20000
Molecular Weight
174kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES20165-1.pdf
Observed Molecular Weight
174 kD
Subcellular Location
Cytoplasm . Nucleus, nucleoplasm . Nucleus . Nucleus, nucleolus .
Other Product Names
DNA topoisomerase 2-alpha (EC 5.99.1.3; DNA topoisomerase II, alpha isozyme)
Gene ID (Human)
7153
SwissProt (Human)
P11388
Available Sizes
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