TOP2A (Phospho Ser1213) rabbit pAb

Catalytic activity: ATP-dependent breakage, passage and rejoining of double-stranded DNA. enzyme regulation: Specifically inhibited by the intercalating agent amsacrine. function: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. miscellaneous: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils. PTM: Phosphorylation has no effect on catalytic activity. similarity: Belongs to the type II topoisomerase family. subcellular location: Generally located in the nucleoplasm. subunit: Homodimer. Interacts with COPS5.