Rifampicin

Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities. Rifampicin shows anti-orthopoxvirus activity.

Product Specifications

CAS Number

[13292-46-1]

Product Name Alternative

Rifampin; Rifamycin AMP

UNSPSC

12352005

Hazard Statement

H302, H362

Target

Antibiotic; Bacterial; Influenza Virus; Orthopoxvirus

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/rifampicin.html

Purity

99.69

Solubility

DMSO : 71.43 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC(C(/C=N/N1CCN(C)CC1)=C(NC(/C(C)=C\C=C\[C@@H]([C@@H]([C@@H](C)[C@H]2O)O)C)=O)C(O)=C3C(O)=C4C)=C3C5=C4O[C@](C)(O/C=C/[C@@H]([C@H]([C@@]([C@@H]2C)([H])OC(C)=O)C)OC)C5=O

Molecular Formula

C43H58N4O12

Molecular Weight

822.94

Precautions

H302, H362

References & Citations

[1]Piriou A, et al. Fatty liver induced by high doses of rifampicin in the rat: possible relation with an inhibition of RNA polymerases in eukariotic cells. Arch Toxicol Suppl. 1979; (2) :333-7.|[2]Yu J, et al. Monitoring in vivo fitness of rifampicin-resistant Staphylococcus aureus mutants in a mouse biofilm infection model. J Antimicrob Chemother. 2005 Apr;55 (4) :528-34. Epub 2005 Mar 2.|[3]Erokhina MV, et al. [In vitro development of rifampicin resistance in the epithelial cells]. Probl Tuberk Bolezn Legk. 2006; (8) :58-61.|[4]Hamzehei M, et al. Inhibition of influenza A virus replication by rifampicin and selenocystamine. J Med Virol. 1980;6 (2) :169-74.|[5]Smee DF, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57 (1-2) :41-52.