Tersolisib
STX-478 (compound 80) is an oral CNS-penetrant allosteric mutant-selective PI3Kα inhibitor. STX-478 shows robust and durable tumor regression and can be used in cancer research[1].
Product Specifications
CAS Number
[2883540-92-7]
Product Name Alternative
STX-478
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/stx-478.html
Concentration
10mM
Purity
99.63
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=NC=C(C=N1)NC(N[C@H](C2=C(C3=CC(F)=CC(F)=C3O2)C)C(F)(F)F)=O
Molecular Formula
C16H12F5N5O2
Molecular Weight
401.29
References & Citations
[1]JR David St Jean, et al. Urea derivatives which can be used to treat cancer. Patent WO2022265993A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Curated Selection
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