O4I1

O4I1 is as a potent Oct3/4 inducer. Target: Oct3/4 O4I1 enhances Oct3/4 gene expression, increases Oct3/4 protein levels, and promotes Oct3/4 mediated transcriptional activation. O4I1 activates Oct3/4 at the transcriptional and translational levels in diverse human cell lines. O4I1 promotes Oct3/4 expression in untransfected HEK293 cells quantified by qRT-PCR after 72 h of treatment. O4I1 is sufficient to enhance Oct3/4 overexpression 2-fold and 3-fold after 48 and 72 h of treatment, respectively.

Product Specifications

CAS Number

[175135-47-4]

UNSPSC

12352005

Hazard Statement

H302

Target

Oct3/4

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/O4I1.html

Purity

98.05

Solubility

DMSO : ≥ 38 mg/mL

Smiles

N#CCC1=CC=C(OCC2=CC=C(OC)C=C2)C=C1

Molecular Formula

C16H15NO2

Molecular Weight

253.30

Precautions

H302

References & Citations

[1]Cheng X, et al. Identification of 2-[4-[ (4-Methoxyphenyl) methoxy]-phenyl]acetonitrile and Derivatives as Potent Oct3/4 Inducers. J Med Chem. 2015 Jun 25;58 (12) :4976-4983.|[2]Mrowka, et al. Method for activating OCT4 for induction of pluripotent stem cell formation. From PCT Int. Appl. (2014), WO 2014000814 A1 20140103.