Ajmaline

Ajmaline (Cardiorythmine) is a sodium channel blocking, class 1A anti-arrhythmic agent. Ajmaline blocks HERG currents with an IC50 of 1 μM in HEK cells and 42.3 μM in Xenopus oocytes. Ajmaline can be used for the research of the ventricular tachyarrhythmia[1][2].

Product Specifications

CAS Number

[4360-12-7]

Product Name Alternative

Cardiorythmine; (+) -Ajmaline

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Sodium Channel

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Ajmaline.html

Concentration

10mM

Purity

99.73

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CN1C2=CC=CC=C2[C@@]34[C@]1([H])[C@@](C[C@H]5[C@H](CC)[C@H]6O)([H])[N@]6[C@]([H])([C@H]5[C@H]4O)C3

Molecular Formula

C20H26N2O2

Molecular Weight

326.43

Precautions

H315, H319, H320

References & Citations

[1]Sparidans RW, et al. Liquid chromatographic assay with fluorescence detection to determine ajmaline in serum from patients with suspected Brugada syndrome. J Chromatogr B Analyt Technol Biomed Life Sci. 2010;878 (23) :2168-2172.|[2]Kiesecker C, et al. Class Ia anti-arrhythmic drug ajmaline blocks HERG potassium channels: mode of action. Naunyn Schmiedebergs Arch Pharmacol. 2004;370 (6) :423-435.