Tubulysin

The Tubulysin family of secondary metabolites was originally isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. These compounds are potent microtubule destabilizers and anti-microtubule toxins (anti-microtubule toxins), with effective IC50 concentrations against multidrug-resistant cancer cell lines. In the picomole range. Tubulysins are ideal candidates for incorporation into small active molecule conjugate (SMDC) delivery systems and are commonly used in ADC synthesis as ADC cytotoxins (ADC Cytotoxin) [1].

Product Specifications

CAS Number

[1943604-24-7]

UNSPSC

12352005

Target

ADC Payload; Antibiotic; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Anti-infection; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tubulysin.html

Purity

99.53

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)[C@@H](C)C[C@@H](NC(C1=CSC([C@H](OC(C)=O)C[C@@H](N(COC(CC(C)C)=O)C([C@@H](NC([C@@H]2N(C)CCCC2)=O)[C@@H](C)CC)=O)C(C)C)=N1)=O)CC3=CC=C(C)C=C3

Molecular Formula

C44H67N5O9S

Molecular Weight

842.10

References & Citations

[1]Leamon CP, et al. Prostate-Specific Membrane Antigen-Specific Antitumor Activity of a Self-Immolative Tubulysin Conjugate. Bioconjug Chem. 2019 Jun 19;30 (6) :1805-1813.