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VTP-27999 (Hydrochloride)

VTP-27999 Hcl is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases. IC50 value: Target: Renin

Product Specifications

CAS Number

[1264191-73-2]

UNSPSC

12352005

Target

Renin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/VTP-27999-Hydrochloride.html

Purity

98.74

Solubility

H2O : ≥ 100 mg/mL

Smiles

O=C(NC[C@H](C[C@@H]1COCCC1)NC)N(CCC2)C[C@]2([H])[C@](OCCNC(OC)=O)([H])C3=CC(Cl)=CC=C3.Cl

Molecular Formula

C26H42Cl2N4O5

Molecular Weight

561.54

References & Citations

[1]Lanqi Jia et al. Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility ACS Med. Chem. Lett., 2011, 2 (10), pp 747-751|[2]New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin. Hypertension. 2013 May;61 (5) :1075-1082.|[3]Ishchenko A, et al. Structure-based design technology contour and its application to the design of Renin inhibitors.J Chem Inf Model. 2012 Aug 27;52 (8) :2089-97. Epub 2012 Jul 25.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Available Sizes

Curated Selection

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