VTP-27999 (Hydrochloride)
VTP-27999 Hcl is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases. IC50 value: Target: Renin
Product Specifications
CAS Number
[1264191-73-2]
UNSPSC
12352005
Target
Renin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/VTP-27999-Hydrochloride.html
Purity
98.74
Solubility
H2O : ≥ 100 mg/mL
Smiles
O=C(NC[C@H](C[C@@H]1COCCC1)NC)N(CCC2)C[C@]2([H])[C@](OCCNC(OC)=O)([H])C3=CC(Cl)=CC=C3.Cl
Molecular Formula
C26H42Cl2N4O5
Molecular Weight
561.54
References & Citations
[1]Lanqi Jia et al. Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility ACS Med. Chem. Lett., 2011, 2 (10), pp 747-751|[2]New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin. Hypertension. 2013 May;61 (5) :1075-1082.|[3]Ishchenko A, et al. Structure-based design technology contour and its application to the design of Renin inhibitors.J Chem Inf Model. 2012 Aug 27;52 (8) :2089-97. Epub 2012 Jul 25.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Curated Selection
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