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8-OH-DPAT (hydrobromide)

8-OH-DPAT (8-Hydroxy-DPAT) hydrobromide is a potent and selective 5-HT1A agonist with a pIC50 of 8.19. 8-OH-DPAT hydrobromide has selectivity of almost 1000 fold for a subtype of the 5-HT1 binding site[1].

Product Specifications

CAS Number

[76135-31-4]

Product Name Alternative

8-Hydroxy-DPAT (hydrobromide)

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/8-oh-dpat-hydrobromide.html

Concentration

10mM

Purity

99.88

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

OC1=C2CC(N(CCC)CCC)CCC2=CC=C1.[H]Br

Molecular Formula

C16H26BrNO

Molecular Weight

328.29

Precautions

H315, H319, H335

References & Citations

1

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

5-HT1 Receptor; mLAG-3

Citation 01

Eur J Pharmacol. 2023 Dec 5:960:176147.|Acta Pharmacol Sin. 2025 Oct 9.|J Ethnopharmacol. 2026 Feb 28:357:120876.|Mol Neurobiol. 2025 Nov 24;63 (1) :163.|Nature. 2024 Jun;630 (8015) :237-246.|Neurochem Int. 2025 Jan 28:105937.|SSRN. 2025 Jun 19.

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