EGA

EGA is an inhibitor that selectively targets the endosomal trafficking pathways. EGA targets the proteins involved in the endosomal trafficking pathways through which multiple toxins and viruses enter cells. EGA exerts its activity by inhibiting the trafficking from early endosomes to late endosomes, blocking the entry of multiple acid-dependent bacterial toxins and viruses into mammalian cells and delaying the lysosomal targeting and degradation of EGFR[1].

Product Specifications

CAS Number

[415687-81-9]

UNSPSC

12352005

Hazard Statement

H315, H319, H335, H410

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ega.html

Purity

99.76

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

BrC1=CC=C(/C=N/NC(NC2=C(C)C=CC=C2C)=O)C=C1

Molecular Formula

C16H16BrN3O

Molecular Weight

346.22

Precautions

H315, H319, H335, H410

References & Citations

[1]Gillespie EJ, et al. Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses. Proc Natl Acad Sci U S A. 2013 Dec 10;110 (50) :E4904-12.