What is the catalog number for NPS-2143?

The catalog number for NPS-2143 is HY-10007.

What sizes are available for NPS-2143?

NPS-2143 is available in the following size(s): 5 mg, 10 mg, 50 mg, 100 mg, 500 mg, 1 g.

How many pack sizes does NPS-2143 come in?

NPS-2143 is available in 6 different pack sizes.

Is NPS-2143 in stock?

NPS-2143 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures NPS-2143?

NPS-2143 is manufactured by QuantiMol.

What is the estimated delivery time for NPS-2143?

Estimated delivery time for NPS-2143 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for NPS-2143?

The safety data sheet for NPS-2143 is available here: http://file.medchemexpress.com/batch_PDF/HY-10007/NPS-2143-SDS-MedChemExpress.pdf.

NPS-2143

NPS-2143 (SB-262470A), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 (SB-262470A) blocks increases in cytoplasmic Ca2+ concentrations (IC50=43 nM) elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor[1][2].

Product Specifications

CAS Number

284035-33-2

Product Name Alternative

SB-262470A

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

CaSR

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/NPS-2143.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#CC1=C(OC[C@@H](CNC(C)(CC2=CC=C3C=CC=CC3=C2)C)O)C=CC=C1Cl

Molecular Formula

C24H25ClN2O2

Molecular Weight

408.92

Precautions

H315, H319, H320

References & Citations

[1]Nemeth EF, et al. Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone. J Pharmacol Exp Ther. 2001 Oct;299 (1) :323-31.|[2]Rybczynska A, et al. Hypertensive effect of calcilytic NPS 2143 administration in rats. J Endocrinol. 2006 Oct;191 (1) :189-95.|[3]Ohsu T, et al. Involvement of the calcium-sensing receptor in human taste perception. J Biol Chem. 2010 Jan 8;285 (2) :1016-22|[4]Nakajima S, et al. Calcium-sensing receptor mediates dietary peptide-induced CCK secretion in enteroendocrine STC-1 cells. Mol Nutr Food Res. 2012 May;56 (5) :753-60|[5]Sun J, et al. Calcium-sensing receptor: a sensor and mediator of ischemic preconditioning in the heart. Am J Physiol Heart Circ Physiol. 2010 Nov;299 (5) :H1309-17.