NXPZ-2
NXPZ-2 is an orally active Keap1-Nrf2 protein–protein interaction (PPI) inhibitor with a Ki value of 95 nM, EC50 value of 120 and 170 nM. NXPZ-2 can dose-dependently ameliorate Aβ[1-42]-Induced cognitive dysfunction, improve brain tissue pathological changes in Alzheimer’s disease (AD) mouse by increasing neuron quantity and function. NXPZ-2 can inhibit oxidative stress by increasing Nrf2 expression levels and promoting its cytoplasm to nuclear translocation, which is helpful for Keap1-Nrf2 PPI inhibitors and AD associated disease research[1].
Product Specifications
CAS Number
2254492-08-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nxpz-2.html
Purity
98.18
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N)CN(C1=C2C=CC=CC2=C(N(CC(N)=O)S(=O)(C3=CC=C(N)C=C3)=O)C=C1)S(=O)(C4=CC=C(OC)C=C4)=O
Molecular Formula
C27H27N5O7S2
Molecular Weight
597.66
Precautions
H302, H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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