MY-1076
MY-1076 is an inhibitor of YAP. MY-1076 induces YAP degradation and cell apoptosis. MY-1076 inhibits MGC-803, SGC-7901, HCT-116 and KYSE450 cells proliferation with IC50 s of 0.019, 0.017, 0.020 and 0.044 μM, respectively[1].
Product Specifications
CAS Number
3008262-76-5
UNSPSC
12352005
Target
Apoptosis; YAP
Type
Reference compound
Related Pathways
Apoptosis; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/my-1076.html
Purity
99.32
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(/C=C/C1=CC(OC)=C(OC)C(OC)=C1)N(C2=CC(OC)=C(OC)C(OC)=C2)CC3=CC(O)=C(OC)C=C3
Molecular Formula
C29H33NO9
Molecular Weight
539.57
References & Citations
[1]Xiang-Jing Fu, et al. Design, synthesis and biological evaluation of N-benzylaryl cinnamide derivatives as tubulin polymerization inhibitors capable of promoting YAP degradation with potent anti-gastric cancer activities, European Journal of Medicinal Chemistry, Volume 262, 2023, 115883.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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