SNIPER (TACC3) -11
SNIPER (TACC3) -11 is a potent FGFR3-TACC3 degrader. SNIPER (TACC3) -11 reduces FGFR3-TACC3 protein levels and suppressed the growth of FGFR3-TACC3 positive cancer cells[1].
Product Specifications
CAS Number
[2906151-68-4]
UNSPSC
12352005
Target
FGFR; SNIPERs
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sniper-tacc3-11.html
Purity
99.58
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN[C@H](C(N[C@@H](C1CCCCC1)C(N2CCC[C@H]2C3=NC(C(C4=CC(OCCOCCOCCNC(C5=CC=C(C=C5)C6=NC(CNC7=NC=CC(NCC(C)C)=N7)=CS6)=O)=CC=C4)=O)=CS3)=O)=O)C
Molecular Formula
C51H66N10O7S2
Molecular Weight
995.26
References & Citations
[1]Shibata N, Cho N, Koyama H, Naito M. Development of a degrader against oncogenic fusion protein FGFR3-TACC3. Bioorg Med Chem Lett. 2022;60:128584.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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