5-Acetylsalicylic acid

5-Acetylsalicylic acid is the derivate of Aspirin (HY-14654), with anti-inflammatory property. 5-Acetylsalicylic acid is the active metabolite of Sulfasalazine (HY-14655) and its production is regulated by beneficial bacteria in the gut but is confined to the intestinal tract. 5-Acetylsalicylic acid exhibits a mild cytotoxicity effect on B16F10 cells. 5-Acetylsalicylic acid can be used for the study of inflammatory bowel disease (IBD) such as ulcerative colitis (UC) [1][2][3].

Product Specifications

CAS Number

[13110-96-8]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/5-acetylsalicylic-acid.html

Concentration

10mM

Purity

99.84

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC(C(C)=O)=CC=C1O

Molecular Formula

C9H8O4

Molecular Weight

180.16

Precautions

H315, H319

References & Citations

[1]Lee HJ, et al. The influence of probiotic treatment on sulfasalazine metabolism in rat. Xenobiotica. 2012 Aug;42 (8) :791-7.|[2]Islam A, et al. Cytotoxicity and apoptotic activity of novel organobismuth (V) and organoantimony (V) complexes in different cancer cell lines. Eur J Med Chem. 2016 Feb 15;109:254-67.|[3]Ishimura A. Prescription of 5-acetylsalicylic Acid Formulations to Patients with Ulcerative Colitis in Japan. Applied Therapeutics. 2024;19:92-4.