AZD3965
AZD3965 is a selective MCT1 inhibitor with a Ki of 1.6 nM, showing 6-fold selectivity over MCT2.
Product Specifications
CAS Number
[1448671-31-5]
UNSPSC
12352005
Hazard Statement
H303, H320
Target
Monocarboxylate Transporter
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AZD3965.html
Concentration
10mM
Purity
99.95
Solubility
DMSO : 40 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1N(C(C)C)C2=C(C(C(N3OC[C@@](C)(O)C3)=O)=C(CC4=C(C)NN=C4C(F)(F)F)S2)C(N1C)=O
Molecular Formula
C21H24F3N5O5S
Molecular Weight
515.51
Precautions
H303, H320
References & Citations
[1]Bola BM, et al. Inhibition of monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport. Mol Cancer Ther. 2014 Dec;13 (12) :2805-16.|[2]Polanski R, et al. Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer. Clin Cancer Res. 2014 Feb 15;20 (4) :926-37.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
MCT1
Available Sizes
Curated Selection
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