TMN355

TMN355 is a potent chemical cyclophilin A inhibitor and reduces foam cell formation and cytokine secretion. TMN355 is used for atherosclerosis[1].

Product Specifications

CAS Number

[1186372-20-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Cyclophilin

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/tmn355.html

Purity

99.67

Solubility

DMSO : 31.25 mg/mL (ultrasonic)

Smiles

O=C(NC(NC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C4=C(F)C=CC=C4Cl

Molecular Formula

C21H14ClFN2O2

Molecular Weight

380.80

Precautions

H302, H315, H319, H335

References & Citations

[1]Ramachandran S, et al. Cyclophilin A enhances macrophage differentiation and lipid uptake in high glucose conditions: a cellular mechanism for accelerated macro vascular disease in diabetes mellitus. Cardiovasc Diabetol. 2016 Nov 3;15 (1) :152.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Cyclophilin A

Available Sizes

Curated Selection

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