TMN355
TMN355 is a potent chemical cyclophilin A inhibitor and reduces foam cell formation and cytokine secretion. TMN355 is used for atherosclerosis[1].
Product Specifications
CAS Number
[1186372-20-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cyclophilin
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/tmn355.html
Purity
99.67
Solubility
DMSO : 31.25 mg/mL (ultrasonic)
Smiles
O=C(NC(NC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C4=C(F)C=CC=C4Cl
Molecular Formula
C21H14ClFN2O2
Molecular Weight
380.80
Precautions
H302, H315, H319, H335
References & Citations
[1]Ramachandran S, et al. Cyclophilin A enhances macrophage differentiation and lipid uptake in high glucose conditions: a cellular mechanism for accelerated macro vascular disease in diabetes mellitus. Cardiovasc Diabetol. 2016 Nov 3;15 (1) :152.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cyclophilin A
Available Sizes
Curated Selection
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