VER-155008
VER-155008 is an inhibitor of Hsp70, with IC50s of 0.5 μM, 2.6 μM, and 2.6 μM for Hsp70, Hsc70 and Grp7, respectively, and with a Kd of 0.3 μM for Hsp70.
Product Specifications
CAS Number
1134156-31-2
UNSPSC
12352005
Hazard Statement
H302
Target
Autophagy; HSP
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/VER-155008.html
Purity
99.82
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=C2N=C(NCC3=CC=C(Cl)C(Cl)=C3)N([C@@H]([C@H](O)[C@@H]4O)O[C@@H]4COCC5=CC=C(C#N)C=C5)C2=NC=N1
Molecular Formula
C25H23Cl2N7O4
Molecular Weight
556.40
Precautions
H302
References & Citations
[1]Massey AJ, et al. A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells. Cancer Chemother Pharmacol. 2010 Aug;66 (3) :535-45.|[2]Yang X, et al. Heat Shock Cognate 70 Inhibitor, VER-155008, Reduces Memory Deficits and Axonal Degeneration in a Mouse Model of Alzheimer's Disease. Front Pharmacol. 2018 Jan 30;9:48.|[3]Kita K, et al. Heat shock protein 70 inhibitors suppress androgen receptor expression in LNCaP95 prostate cancer cells. Cancer Sci. 2017 Sep;108 (9) :1820-1827.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP70
Available Sizes
Frequently Asked Questions
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