VER-155008

VER-155008 is an inhibitor of Hsp70, with IC50s of 0.5 μM, 2.6 μM, and 2.6 μM for Hsp70, Hsc70 and Grp7, respectively, and with a Kd of 0.3 μM for Hsp70.

Product Specifications

CAS Number

[1134156-31-2]

UNSPSC

12352005

Hazard Statement

H302

Target

Autophagy; HSP

Type

Reference compound

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/VER-155008.html

Purity

99.82

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=C2N=C(NCC3=CC=C(Cl)C(Cl)=C3)N([C@@H]([C@H](O)[C@@H]4O)O[C@@H]4COCC5=CC=C(C#N)C=C5)C2=NC=N1

Molecular Formula

C25H23Cl2N7O4

Molecular Weight

556.40

Precautions

H302

References & Citations

[1]Massey AJ, et al. A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells. Cancer Chemother Pharmacol. 2010 Aug;66 (3) :535-45.|[2]Yang X, et al. Heat Shock Cognate 70 Inhibitor, VER-155008, Reduces Memory Deficits and Axonal Degeneration in a Mouse Model of Alzheimer's Disease. Front Pharmacol. 2018 Jan 30;9:48.|[3]Kita K, et al. Heat shock protein 70 inhibitors suppress androgen receptor expression in LNCaP95 prostate cancer cells. Cancer Sci. 2017 Sep;108 (9) :1820-1827.