TUG-1375

TUG-1375 is an agonist of free fatty acid receptor 2 (FFA2/GPR43), with a pKi of 6.69. TUG-1375 is inactive on FFA3, FFA4, PPARα, PPARγ, PPARδ, LXRα or LXRβ[1].

Product Specifications

CAS Number

[2247372-59-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Free Fatty Acid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/TUG-1375.html

Concentration

10mM

Purity

99.42

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(N1[C@@H](C2=CC=CC=C2Cl)SC[C@H]1C(O)=O)C3=CC=C(C4=C(C)ON=C4C)C=C3

Molecular Formula

C22H19ClN2O4S

Molecular Weight

442.92

Precautions

H302, H315, H319, H335

References & Citations

[1]Hansen AH, et al. Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties. J Med Chem. 2018 Nov 8;61 (21) :9534-9550.