MLK-IN-2

MLK-IN-2 (Compound 9a) is a Mixed Lineage Kinase 3 (MLK3) inhibitor containing 3H-imidazole [4,5-b] pyridine structure. IC50 value is 6 nM. MLK-IN-2 can be used to study cancer and neurodegenerative diseases[1].

Product Specifications

CAS Number

[2614255-51-3]

UNSPSC

12352005

Target

Mixed Lineage Kinase

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mlk-in-2.html

Purity

98.22

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N1CCOCC1)C2=CC=CC(N3C(C)=C(C4=NC(C(N[C@H]5CCN(S(CC)(=O)=O)C5)=C(Br)C=N6)=C6N4)C=C3C)=C2

Molecular Formula

C29H34BrN7O4S

Molecular Weight

656.59

References & Citations

[1]Yoon HR, et al. Design, synthesis of new 3H-imidazo[4,5-b]pyridine derivatives and evaluation of their inhibitory properties as mixed lineage kinase 3 inhibitors. Bioorg Med Chem Lett. 2024 Feb 10;101:129652.