Antitumor agent-173

Antitumor agent-173 (Compound 4b) is a prodrug of Cycloicaritin (HY-N1940) . Antitumor agent-173 is a substrate for OATP2B1. Antitumor agent-173 selectively inhibits the growth of tumor Antitumor agent-173 significantly increases the oral bioavailability of Cycloicaritin and exerts good antitumor activity and safety[1].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352005

Target

Interleukin Related; MMP; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/antitumor-agent-173.html

Smiles

COC(C=C1)=CC=C1C2=C(OC(N[C@@H](CC(C)C)C(O)=O)=O)C(C3=C(O)C=C4C(CCC(C)(C)O4)=C3O2)=O

Molecular Formula

C28H31NO9

Molecular Weight

525.55

References & Citations

[1]Wang W, et al. Design, synthesis and evaluation of carbamate-bridged amino acid prodrugs of cycloicaritin with improved antitumor activity, aqueous solubility and phase II metabolic stability. Eur J Med Chem. 2024 Jul 2;276:116646.