CD74 Polyclonal Antibody

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. Class-II-associated invariant chain peptide Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome.1 Publication Isoform p41 Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs) . Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2. Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform.

CD 74; CD74 antigen; CD74 antigen (invariant polypeptide of major histocompatibility complex; CD74 molecule; class II antigen-associated) ; class II invariant chain; CLIP; Gamma chain of class II antigens; HG2A; HLA DR antigens associated invariant chain; HLA DR gamma; HLADR antigens associated invariant chain; HLA-DR antigens-associated invariant chain; HLA-DR-gamma; Ia antigen associated invariant chain; Ia associated invariant chain; Ia gamma; Ia-GAMMA; Invariant polypeptide of major histocompatibility complex class II antigen associated; la-gamma; major histocompatibility complex; Major histocompatibility complex class II invariant chain; MHC HLA DR gamma chain; MHC HLA-DR gamma chain; p35; Protein 41; CD74; DHLAG; HLA class II histocompatibility antigen gamma chain; HLADG; Ia antigen-associated invariant chain; p33; CD 14; CD_antigen=CD14; CD14; CD14 antigen; CD14 molecule; LPS-R; Mo2; Monocyte differentiation antigen CD14; Monocyte differentiation antigen CD14 urinary form; membrane-bound form; Myeloid cell specific leucine rich glycoprotein; Myeloid cell-specific leucine-rich glycoprotein; HLA class II histocompatibility antigen gamma chain; HLADG; Ia antigen-associated invariant chain; Ia-GAMMA II; Ii; p33; CD74 HLA-DR antigens-associated invariant chain; DHLAG; CD74; invariant chain