Axelopran (sulfate)

Axelopran sulfate is an opioid receptor antagonist with pKi values of 9.8, 8.8 and 9.9 for human recombinant μ and δ receptors and guinea pig κ receptor, respectively.

Product Specifications

CAS Number

[949904-50-1]

Product Name Alternative

TD-1211 (sulfate)

UNSPSC

12352005

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/axelopran-sulfate.html

Purity

99.14

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C([C@@H](O)CO)N(CC1CCCCC1)CCN2[C@H]3C[C@H](C4=CC(C(N)=O)=CC=C4)C[C@@H]2CC3.O=S(O)(O)=O

Molecular Formula

C26H41N3O8S

Molecular Weight

555.68

References & Citations

[1]Tsuruda PR, et al., The in vitro pharmacological profile of TD-1211, a neutral opioid receptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 2013 Jun;386 (6) :479-91.