ML354
ML354 is a selective PAR4 antagonist with an IC50 of 140 nM[1].
Product Specifications
CAS Number
[89159-60-4]
Product Name Alternative
VU0099704
UNSPSC
12352005
Hazard Statement
H301
Target
Protease Activated Receptor (PAR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ml354.html
Purity
98.80
Solubility
DMSO : 28.2 mg/mL (ultrasonic; warming)
Smiles
OCC(N1C)=C(C2=CC=CC=C2)C3=C1C=CC([N+]([O-])=O)=C3
Molecular Formula
C16H14N2O3
Molecular Weight
282.29
Precautions
H301
References & Citations
[1]Wen W, et al. Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354. Bioorg Med Chem Lett. 2014 Oct 1;24 (19) :4708-4713.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAR4
Available Sizes
Curated Selection
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