ML354

ML354 is a selective PAR4 antagonist with an IC50 of 140 nM[1].

Product Specifications

CAS Number

[89159-60-4]

Product Name Alternative

VU0099704

UNSPSC

12352005

Hazard Statement

H301

Target

Protease Activated Receptor (PAR)

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ml354.html

Purity

98.80

Solubility

DMSO : 28.2 mg/mL (ultrasonic; warming)

Smiles

OCC(N1C)=C(C2=CC=CC=C2)C3=C1C=CC([N+]([O-])=O)=C3

Molecular Formula

C16H14N2O3

Molecular Weight

282.29

Precautions

H301

References & Citations

[1]Wen W, et al. Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354. Bioorg Med Chem Lett. 2014 Oct 1;24 (19) :4708-4713.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PAR4

Available Sizes

Curated Selection

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