SD-436

SD-436 is a highly selective and efficacious STAT3 PROTAC degrader (DC50: 0.5 μM), with IC50 of 19 nM (STAT3), 270 nM (STAT1), 360 nM (STAT4), >10 μM (STAT5) and >10 μM (STAT6) . SD-436 promotes ubiquitination and degradation of STAT3, and induces tumor regression. SD-436 can be used for tumor research, such as leukemia and lymphoma (Pink: STAT3 ligand (HY-169361) ; Blue: E3 ligase ligand (HY-43722) ; Black: linker (HY-147052) [1].

Product Specifications

CAS Number

[2497585-50-7]

UNSPSC

12352005

Target

PROTACs; STAT

Type

Reference compound

Related Pathways

JAK/STAT Signaling; PROTAC; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sd-436.html

Purity

98.27

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1[C@H](CN(CC[C@@H]2N1[C@@H](CC2)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N3CCC(CC3)CCC#CC4=CC=CC5=C4CN(C5=O)C6CCC(NC6=O)=O)=O)CC7=CC=C(C(F)=C7)F)=O)=O)C(OC)=O)NC(C8=CC9=C(S8)C=CC(C(F)(P(O)(O)=O)F)=C9)=O

Molecular Formula

C58H62F4N9O14PS

Molecular Weight

1248.20

References & Citations

[1]Xu, et al. Discovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression. Journal of medicinal chemistry. 2024, 67 (22), 20495–20513.