SMTIN-T140

SMTIN-T140 (compound 6a) is a potent TRAP1 (tumor-necrosis-factor-receptor associated protein 1) inhibitor, with an IC50 of 1.646 μM. SMTIN-T140 shows anticancer activity. SMTIN-T140 leads to mitochondrial dysfunction, increases mitochondrial ROS production and activates AMPK. SMTIN-T140 potently suppressed tumor growth without any noticeable in vivo toxicity in a mouse model xenografted with PC3 prostate cancer cells[1].

Product Specifications

CAS Number

[2851532-40-4]

UNSPSC

12352005

Target

AMPK; HSP; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/smtin-t140.html

Purity

99.58

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=NC(Cl)=C2C(N(C(N2CCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=O)CC6=C(C=C(C=C6)Br)F)=N1

Molecular Formula

C36H34BrClFN5OP+

Molecular Weight

718.02

References & Citations

[1]Yang S, et al. Triphenylphosphonium conjugation to a TRAP1 inhibitor, 2-amino-6-chloro-7,9-dihydro-8H-purin-8-one increases antiproliferative activity. Bioorg Chem. 2022 May 20;126:105856.