Mca-P-Cha-G-Nva-HA-Dap (DNP) -NH2

Mca-P-Cha-G-Nva-HA-Dap (DNP) -NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-26. Mca-P-Cha-G-Nva-HA-Dap (DNP) -NH2 can be used to quantify MMP-1, MMP-3 and MMP-26 activity[1][2].

Product Specifications

CAS Number

[256394-94-2]

UNSPSC

12171500

Target

MMP

Type

Dye Reagents

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/mca-p-cha-g-nva-ha-dap-dnp-nh2.html

Solubility

10 mM in DMSO

Smiles

O=C(N(CCC1)[C@@H]1C(N[C@H](C(NCC(N[C@@H](CCC)C(N[C@H](C(N[C@@H](C)C(N[C@H](C(N)=O)CNC(C=CC([N+]([O-])=O)=C2)=C2[N+]([O-])=O)=O)=O)CC3=CN=CN3)=O)=O)=O)CC4CCCCC4)=O)CC(C(C(O5)=C6)=CC=C6OC)=CC5=O

Molecular Formula

C51H65N13O15

Molecular Weight

1100.14

References & Citations

[1]Park HI, et al. Peptide substrate specificities and protein cleavage sites of human endometase/matrilysin-2/matrix metalloproteinase-26. J Biol Chem. 2002 Sep 20;277 (38) :35168-75.|[2]Knäuper V, et al. The role of exon 5 in fibroblast collagenase (MMP-1) substrate specificity and inhibitor selectivity. Eur J Biochem. 2001 Mar;268 (6) :1888-96.