Defensin HNP-1 human

Defensin HNP-1 human is a type of human neutrophil peptide (HNPs) . Defensin HNP-1 human possesses immunomodulatory functions and can delay the apoptosis of neutrophils. Defensin HNP-1 human inhibits DNA/RNA/protein synthesis and interferes with metabolic pathways, thus exhibiting broad antibacterial activity. Defensin HNP-1 human has direct inactivation effects on HIV, HSV-1, HSV-2, CMV, influenza virus, etc. Defensin HNP-1 human has antileishmanial activity. Defensin HNP-1 human is involved in endothelial cell dysfunction during the early development of atherosclerosis[1][2][3].

Product Specifications

CAS Number

[148093-65-6]

UNSPSC

12352209

Target

Apoptosis; Bacterial; CMV; DNA/RNA Synthesis; HIV; HSV; Influenza Virus; NOD-like Receptor (NLR) ; Parasite; TNF Receptor

Type

Peptides

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cardiovascular Disease; Infection

Assay Protocol

https://www.medchemexpress.com/defensin-hnp-1-human.html

Purity

98.12

Solubility

H2O

Smiles

O=C([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@](NC([C@@]1([H])NC([C@](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@](NC([C@]2([H])CSSC[C@](C(N[C@@H](CSSC[C@@H](C(N[C@H](C(N[C@](CSSC1)([H])C(N[C@H](C(N[C@@](C(N3[C@](CCC3)([H])C(N[C@H](C(N2)=O)C)=O)=O)([H])[C@@H](C)CC)=O)CCCNC(N)=N)=O)=O)CC4=CC=C(C=C4)O)=O)NC([C@@H](N)C)=O)C(O)=O)=O)([H])NC([C@@H](NC([C@@H](NC5=O)C)=O)CC6=CC=CC=C6)=O)=O)([H])[C@@H](C)CC)=O)C)=O)=O)CCC(O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC7=CC=C(C=C7)O)=O)=O)([H])[C@H](O)C)=O)=O)([H])[C@@H](C)CC)=O)CC8=CC=C(C=C8)O)=O)CCC(N)=O)=O)=O)CCCNC(N)=N)=O)CC(C)C)N[C@H]5CC9=CNC%10=CC=CC=C9%10

Molecular Formula

C150H222N44O38S6

Molecular Weight

3442.03

References & Citations

[1]Dabirian S, et, al. Human neutrophil peptide-1 (HNP-1) : a new anti-leishmanial drug candidate. PLoS Negl Trop Dis. 2013 Oct 17;7 (10) :e2491.|[2]Higazi M, et, al. Opposing effects of HNP1 (α-defensin-1) on plasma cholesterol and atherogenesis. PLoS One. 2020 Apr 17;15 (4) :e0231582.|[3]Zhang J, et al. HNP-1: From Structure to Application Thanks to Multifaceted Functions. Microorganisms. 2025 Feb 19;13 (2) :458.