Lysozyme

Lysozyme (Muramidase) is a conserved antimicrobial protein. Lysozyme exerts its bactericidal effect by hydrolyzing bacterial cell wall peptidoglycan (PG) . Lysozyme plays an important role in limiting bacterial growth on mucosal surfaces and other sites, not only controlling potential pathogens but also limiting overgrowth of microbiota to prevent dysbiosis. Extracellular lysozyme can also degrade polymeric PG into soluble fragments, activate NOD receptors in mucosal epithelial cells, and lead to the secretion of chemokines and activating factors by neutrophils and macrophages[1][2].

Product Specifications

CAS Number

[9001-63-2]

Product Name Alternative

Muramidase

UNSPSC

12352204

Hazard Statement

H334

Target

Bacterial; Interleukin Related; TGF-β Receptor; TNF Receptor

Type

Enzyme

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/lysozyme.html

Purity

95.0

Solubility

H2O : 4.76 mg/mL (ultrasonic; adjust pH to 4 with 0.1 M HCl)

Smiles

[Lysozyme]

Precautions

P261-P284-P304+P340-P501

References & Citations

[1]Feingold DS, et al. Locus of the action of serum and the role of lysozyme in the serum bactericidal reaction. J Bacteriol. 1968 Dec;96 (6) :2118-26.|[2]Ragland S A, et al. From bacterial killing to immune modulation: Recent insights into the functions of lysozyme[J]. PLoS pathogens, 2017, 13 (9) : e1006512.|[3]Markart P, et al. Mouse lysozyme M is important in pulmonary host defense against Klebsiella pneumoniae infection[J]. American journal of respiratory and critical care medicine, 2004, 169 (4) : 454-458.|[4]Lee M, et al. Hen egg lysozyme attenuates inflammation and modulates local gene expression in a porcine model of dextran sodium sulfate (DSS) -induced colitis[J]. Journal of agricultural and food chemistry, 2009, 57 (6) : 2233-2240.