Thymine-d4
Thymine-d4 is the deuterium labeled Thymine. Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM.
Product Specifications
CAS Number
200496-79-3
UNSPSC
12352005
Hazard Statement
H319
Target
Endogenous Metabolite; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer; Metabolic Disease
Purity
98
Solubility
10 mM in DMSO
Smiles
O=C1C(C([2H])([2H])[2H])=C([2H])NC(N1)=O
Molecular Formula
C5H2D4N2O2
Molecular Weight
130.14
Precautions
H319
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Tuchman M, et al. Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase. Cancer Res. 1985 Nov;45 (11 Pt 1) :5553-6.
Shipping Conditions
Room Temperature
Storage Conditions
RT, sealed storage, away from moisture and light
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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