Pesampator

Pesampator (PF-04958242) is a potent and highly selective positive allosteric modulator of AMPA receptor (an AMPA potentiator) with an EC50 of 310 nM and a Ki of 170 nM[1].

Product Specifications

CAS Number

[1258963-59-5]

Product Name Alternative

PF-04958242

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pesampator.html

Purity

99.85

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(S(=O)(N[C@H]1COC[C@H]1OC2=CC=C(C3=CC=C(C#N)S3)C=C2)=O)C

Molecular Formula

C18H20N2O4S2

Molecular Weight

392.49

References & Citations

[1]Shaffer CL, et al. The discovery and characterization of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiator N-{ (3S,4S) -4-[4- (5-cyano-2-thienyl) phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242) . J Med Chem. 2015;58 (10) :4291-4308.