Thioproperazine

Thioproperazine (RP 7843) is an orally active antipsychotic agent with calming, antiemetic activity. Thioproperazine is effective in promoting the release of dopamine in rat striatum. Thioproperazine can be used in studies of schizophrenia and bipolar disorder[1].

Product Specifications

CAS Number

[316-81-4]

Product Name Alternative

RP 7843; SKF 5883; Thioperazine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/thioproperazine.html

Purity

99.90

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 70°C)

Smiles

O=S(C(C=C1N2CCCN3CCN(C)CC3)=CC=C1SC4=C2C=CC=C4)(N(C)C)=O

Molecular Formula

C22H30N4O2S2

Molecular Weight

446.63

Precautions

H302, H315, H319, H335

References & Citations

[1]Cheramy A, et al. Increased release of dopane from striatal dopaminergic terminals in the rat after treatment with a neuroleptic: thioproperazine. Eur J Pharmacol. 1970 May;10 (2) :206-14.