Hydrocortisone cypionate

Hydrocortisone cypionate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester.

Product Specifications

CAS Number

[508-99-6]

UNSPSC

12352211

Hazard Statement

H315-H319-H320

Target

Glucocorticoid Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Hydrocortisone_cypionate.html

Concentration

10mM

Purity

98.04

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

C[C@@]1([C@@]2(O)C(COC(CCC3CCCC3)=O)=O)[C@](CC2)([H])[C@@](CCC4=CC5=O)([H])[C@]([C@]4(CC5)C)([H])[C@@H](O)C1

Molecular Formula

C29H42O6

Molecular Weight

486.64

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]F?rster C, et al. Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol. 2008 Apr 1;586 (7) :1937-49.|[2]Bellinghausen I, et al. Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol. 2001 Aug;108 (2) :242-9.|[3]Chappell D, et al. Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology. 2007 Nov;107 (5) :776-84.