Val-Cit

Val-Cit is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].

Product Specifications

CAS Number

[159858-33-0]

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/val-cit.html

Purity

99.76

Solubility

H2O : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)[C@H](CCCNC(N)=O)NC([C@H](C(C)C)N)=O

Molecular Formula

C11H22N4O4

Molecular Weight

274.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

Cleavable Linker; Protease Cleavable Linker

Available Sizes

Curated Selection

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