Didesethyl chloroquine

Didesethyl chloroquine (Bisdesethylchloroquine) is a major metabolite of the antimalarial agent Chloroquine. Didesethyl chloroquine is a potent myocardial depressant[1][2].

Product Specifications

CAS Number

[4298-14-0]

Product Name Alternative

Bisdesethylchloroquine

UNSPSC

12352005

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/didesethyl-chloroquine.html

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCN

Molecular Formula

C14H18ClN3

Molecular Weight

263.77

References & Citations

[1]Biot C, et al. Synthesis and antimalarial activity in vitro of potential metabolites of ferrochloroquine and related compounds. Bioorg Med Chem. 1999 Dec;7 (12) :2843-7.|[2]Essien EE, et al. Effects of chloroquine and didesethylchloroquine on rabbit myocardium and mitochondria. J Pharm Pharmacol. 1986 Jul;38 (7) :543-6.